Well Differentiated Papillary Mesothelioma Treatment
Papillary mesothelioma with a well-differentiated pattern is most prevalent in the lining which is found on the abdomen (peritoneum). It can also occur in the pleura surrounding the lungs, and the tunica vulginalis of testes.
Mesothelioma can be a deadly cancer, but this kind has a low malignant potential and usually responds to treatment. However, it can be recurrent and can progress to more advanced forms of cancer.
Signs and symptoms
Papillary mesothelioma that is differentiated is found on the membranes around different organs. It is most commonly found in the peritoneum. However, it can be found on the pleurae (lining of the lungs) as well as the pericardiums (a sac surrounding the heart), and tunica vaginaliss (the tissue that surrounds the testicles). While mesothelioma generally is a cancerous disease, some kinds are considered to be benign. These are mesotheliomas of low grade that typically have a better outlook than malignant mesothelioma.
Asbestos exposure is a major cause of mesothelioma. In certain cases, a person affected by this disease may not experience symptoms until several years after exposure to asbestos. Therefore, doctors must determine the condition through a physical examination and taking blood samples for laboratory testing. They also use imaging techniques, such as x-rays, MRIs and PET scans, to look for any symptoms of mesothelioma.
The treatment of mesothelioma is the most efficient when the tumors are treated and detected early, prior to their progression into malignant forms. Many experts on mesothelioma suggest routine follow-ups in order to detect any changes. However a case report published in the Journal of Medical Ultrasound showed that regular imaging follow-ups might not be necessary for well differentiated papillary mesothelioma.
The report analyzed the first instance of WDPM discovered concurrently with a struma ovarii, which is a rare tumor in the serosal tissue surrounding the uterus. The patient had abdominal pain that was accompanied by painful debulking laparoscopy. The pathology that resulted revealed a non-invasive papillary growth of mesothelial cells with retained labelling for BAP1 as deemed appropriate under the new WHO classification.
According to the study, WDPM is a benign tumor that is rarely transformed into mesothelioma that is invasive. The authors of the study note that epithelioid mesotheliomas that are invasive and are clear can also resemble WDPM.
Diagnosis
In many cases, abdominal pain or swelling are the first signs. The condition can also cause swelling of the lungs or abdomen. It is important that you get a diagnosis by an experienced doctor. Mesothelioma may be classified as epithelial or sarcomatoid biphasic. WDPM is different from mesothelioma that is malignant and can quickly spread to other parts of the human body, is usually benign.
The majority of mesotheliomas can be classified based on their cell type. The most frequent type is epithelial, and the most rare is sarcomatoid. But a few studies have examined the possibility that mesothelioma could evolve into a well-differentiated, mesothelioma papillary. While sarcomatoid mesothelioma has an extremely low prognosis, well-differentiated papillary mesothelioma is thought to be of low-risk.
In the medical literature, only 14 cases of papillary mesothelioma that had an appropriately differentiated tumor were discovered until recently. The rare tumor is found in the lining of specific organs, such as the pleura and the peritoneum. The exact cause is unclear, but it is believed that exposure to asbestos is the cause.
The WDPM tumor grows in the lining of the organ it targets, which is most often the peritoneum. It can also occur in the pleura (the sac that surrounds lungs) and tunica vaginalis which is the testes' tunica vaginalis.
WDPM is a low-grade form of mesothelioma that can develop into malignant mesothelioma over time. Certain patients have developed malignant mesothelioma and WDPM in the same place in their bodies.
Doctors detect WDPM by taking an sample of the affected tissue and performing tests in the laboratory. These tests are performed to detect the presence of cancerous cells as well as their level of differentiation. If a patient is diagnosed with this condition it is recommended that they attend regular follow up appointments to make sure that the tumor doesn't grow or recur. WDPM could be misdiagnosed or mistaken as benign mesothelioma. It is therefore important that doctors know the unique nature of WDPM and the possibility of recurrence. If this condition recurs, you should consult an experienced mesothelioma attorney to discuss your options.
radiation treatment in mesothelioma of papillary mesothelioma that is well differentiated is generally successful and often leads to a better prognosis than other types of mesothelioma. However, as with other mesothelioma types should consult an expert doctor to make sure they have the right diagnosis and best treatment options.
The first step of mesothelioma therapy is to remove the cancerous or tumor-causing tissues from the body area affected. The surgeon can also utilize radiation therapy or chemotherapy to kill any remaining cancerous cells and stop the development of new tumors in the future.
Doctors have also seen mesothelioma elsewhere in the body, such as the pericardium, tunica vulginalis, and pleura. In the case of WDPMT the tumors are typically seen as nodules that are white to gray that range from one to three centimeters wide. The tumors grow slowly but they may cause pain and swelling as they grow.
The cell structure of papillary mesothelioma that is well differentiated is unique, and it sets it apart from other mesothelioma types. The tumors exhibit an elongated pattern of mesothelial cells that are bland that form finger-like projections known as papillae. The papillae are found in the peritoneum lining, but also in pleura and testicles.
WDPM, epithelial varieties of mesothelioma as well as other cellular structures must be distinguished from malignant, sarcomatoid, mesothelioma. This cancer has a more aggressive course. Sarcomatoid cells in mesothelioma are more likely than other mesothelioma types to grow quickly and spread throughout the body.
Sarcomatoid Mesothelioma, on other hand, is more likely to be associated with smoking than exposure to asbestos. Yet, the link between mesothelioma and asbestos remains unclear. Asbestos can be a factor in the development of malignant and benign types of mesothelioma. However it is not believed to be a cause for WDPM. Numerous studies have demonstrated that solitary WDPM may progress to mesothelioma malign in a small subset of patients, but it isn't known who is most at risk of this development. For those whose solitary WDPM has a decrease in BAP 1 and the MTAP, there is a higher chance that their tumor will take a more aggressive clinical course.
Prevention
Papillary mesothelioma occurs most commonly in the linings of the abdomen (peritoneum), and less often, in the linings of the testicles and lungs. This subtype is benign and has a good prognosis. However, a rare chance of developing into malignant mesothelioma is. The cancer is believed to be caused by asbestos, which is a carcinogen. But, researchers continue to look to determine the possible causes.
In a few cases, WDPM can transform into malignant mesothelioma of the pleural. This is a rare situation. However it is crucial that you seek medical attention and diagnosis as soon as you can if you have any of the symptoms.
WDPM and sarcomatoid-sarcomatoid sarcomatoid are two kinds of malignant tumors that differ in their cell structure and outlook. WDPM is generally epithelial whereas the sarcomatoid type is more often a sarcomatoid cancer. Biphasic mesothelioma can be found and can exhibit epithelial as well as sarcomatoid characteristics.
The mesothelioma type is generally benign and has a better prognosis when compared to other malignant types. This is especially relevant when it is detected in the peritoneum. However, it may pose significant health concerns and is difficult to treat in the pleura or tunica vaginalis.
Typically, doctors diagnose this type of mesothelioma when it is discovered during surgery for another condition or by chance in a patient with abdominal pain and/or fluid buildup. A biopsy is the only method to confirm the diagnosis with certainty.
Patients who have a history of asbestos exposure should be evaluated and treated by a mesothelioma specialist who is knowledgeable about the most recent research. Patients have reported three-year survival rates of up 60 percent when combined with aggressive locoregional treatment that includes cytoreductive surgical removal of all gross diseases, and hyperthermic intraperitoneal chemotherapy to eradicate the disease in a microscopic way. This is far more than the median survival rate of historic controls. Therefore, it is essential to seek out a mesothelioma-referral center.